Mood Support

Lion’s Mane and Brain Health

Why real science supports the buzz

Lion’s Mane (Hericium erinaceus) isn’t just a wellness trend, it’s one of the most researched functional mushrooms for brain health and cognitive performance.
Its naturally occurring compounds, hericenones (from the fruiting body) and erinacines (from the mycelium), have been shown in multiple laboratory studies to stimulate Nerve Growth Factor (NGF), a protein essential for the growth and repair of brain cells (Mori et al., 2008; Wong et al., 2021).
This NGF-supporting activity is one reason Lion’s Mane has attracted scientific attention for memory, focus, and mood balance.

Human Studies That Support the Science

• Memory and cognitive function:
  In a Japanese double-blind, placebo-controlled study, older adults who took Lion’s Mane daily for 16 weeks showed significant improvements in cognitive test scores compared to placebo. When supplementation stopped, scores gradually declined, suggesting the benefits were linked to consistent use (Mori et al., 2009).
• Mood and wellbeing:
  Another small human study found that women taking Lion’s Mane for four weeks reported reduced feelings of irritability and anxiety compared to placebo (Nagano et al., 2010).
  Additional trials have since supported its potential to help balance mood and mental clarity, especially under stress (Vigna et al., 2019; Docherty et al., 2023).
• Neuroprotection and healthy ageing:
  Preclinical work suggests Lion’s Mane compounds can help protect neurons from oxidative stress and age-related decline, offering a promising area of ongoing research into healthy cognitive ageing (Spangenberg et al., 2025).

Why Boss B Lion’s Mane Stands Out

Boss B doesn’t cut corners. Each gummy delivers a high-potency extract derived from 7,500 mg of certified-organic Lion’s Mane (fruiting body only), a clinical-strength dosage aligned with the human trials above.
Our formulation is dual-extracted for optimal bioavailability and independently tested, so every serving delivers the same quality you see in the research, just in one delicious, vegan gummy.

Safety and Tolerability

Lion’s Mane has an excellent safety record.
Across human studies, no serious side effects have been reported, and it is generally well tolerated in healthy adults (Nagano et al., 2010; Vigna et al., 2019).
That means if you’re curious about supporting your focus, mood, or long-term brain health, there’s little downside to adding Lion’s Mane to your daily routine, especially when using a high-quality, food-supplement formulation like Boss B.
(Always consult your GP if pregnant, breastfeeding, or taking medication.)

The Takeaway

Lion’s Mane has been studied for its ability to support memory, focus, and overall cognitive wellbeing, with emerging evidence pointing to benefits for mood and mental clarity.
While research is still growing, the science so far is promising and with no known adverse effects, Lion’s Mane represents a safe, evidence-based way to invest in your brain health.

References

1. Mori K et al. (2008). NGF-Inducing Activity of Hericium erinaceus and Increased Hippocampal NGF mRNA in Mice. Biol Pharm Bull.

2. Mori K et al. (2009). Improvement of Cognitive Functions by Oral Intake of Hericium erinaceus in a Double-Blind Placebo-Controlled Clinical Trial. Phytother Res.

3. Nagano M et al. (2010). Reduction of Depression and Anxiety by Four Weeks Hericium erinaceus Intake in Women. Biomed Res.

4. Vigna L et al. (2019). Hericium erinaceus Improves Mood and Sleep Disorders in Patients Affected by Overweight or Obesity. Evid-Based Complement Altern Med.

5. Docherty S et al. (2023). The Acute and Chronic Effects of Lion’s Mane on Cognition and Stress in Healthy Adults. Nutrients.

6. Wong K-H et al. (2021). A Review on Hericium erinaceus Bioactive Compounds and Neuroprotective Mechanisms. J. Med. Food.

7. Spangenberg E et al. (2025). Unveiling the Role of Erinacines in Neuroprotective Effects of Lion’s Mane Mushroom. Front Pharmacol.

Disclaimer

Food supplement. Not intended to diagnose, treat, cure, or prevent any disease. Results may vary. Always consult a healthcare professional before making changes to your supplement routine.