Burnout study

Lion’s Mane (Hericium erinaceus) and Burnout: Evidence-Based Insights 

Burnout is increasingly recognized as a serious health concern, characterized by physical and emotional exhaustion, reduced productivity, and impaired cognitive function. Emerging research suggests that Lion’s Mane mushroom (Hericium erinaceus), when taken at high-potency dosages such as 7,500 mg daily, may offer neuroprotective benefits that support resilience against the effects of chronic stress.

Lion’s Mane contains bioactive compounds that stimulate Nerve Growth Factor (NGF), which plays a crucial role in maintaining and repairing neurons (Zhang et al., 2021). By enhancing neurogenesis and synaptic plasticity, Lion’s Mane may contribute to improved cognitive performance, a critical factor in addressing the mental fatigue associated with burnout.

Clinical studies further support its potential. Mori et al. (2009) conducted a double-blind, placebo-controlled trial demonstrating that supplementation with Lion’s Mane significantly improved mild cognitive impairment in older adults. These findings highlight its role in supporting brain function under conditions of stress and decline.

In addition, Vigna et al. (2019) reported that Hericium erinaceus supplementation improved mood and sleep quality in individuals affected by overweight and obesity, suggesting potential benefits for mood regulation and restorative sleep—two dimensions often disrupted in burnout.

Taken together, this evidence suggests that Lion’s Mane at clinically relevant doses could be a valuable natural support for individuals experiencing or recovering from burnout, particularly when integrated within a broader lifestyle and clinical management plan.

At BossB, our focus is on presenting supplements with strong scientific grounding, ensuring that consumers and health professionals alike can make informed decisions supported by peer-reviewed research.

Author: Roisin Doyle – Health Science Consultant at Boss B

References

Mori, K., Inatomi, S., Ouchi, K., Azumi, Y., & Tuchida, T. (2009). Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: A double-blind placebo-controlled clinical trial. Phytotherapy Research, 23(3), 367–372. https://doi.org/10.1002/ptr.2634

Vigna, L., Morelli, F., Agnelli, G. M., Napolitano, F., Ratto, D., Occhinegro, A., & Savino, E. (2019). Hericium erinaceus improves mood and sleep disorders in patients affected by overweight or obesity: A pilot study. Evidence-Based Complementary and Alternative Medicine, 2019, 1–9. https://doi.org/10.1155/2019/7861297

Zhang, J., An, Y., Gao, J., Han, J., Pan, R., Wang, C., … & Guo, H. (2021). Neuroprotective effects of Hericium erinaceus (Lion’s Mane) mushroom: A review of clinical and animal studies. Frontiers in Aging Neuroscience, 13, 738582. https://doi.org/10.3389/fnagi.2021.738582

Sleep

Mood support

What do we actually know about Lion's mane and the brain?

Lion's mane is not just a wellness hype, there is real science behind it. Roisin Doyle, MSc Science (Adolescent Health) for Boss B

Multiple studies have shown that the compounds found in lion's mane, stimulate nerve growth factor (NGF). One Japanese study of older adults who took lion's mane, showed significant improvements in memory function after just 16 weeks. Another study found that Lion's mane helps protect the brain from age-related decline and can even support your mood.

But Boss B Lion's mane does not cut corners. Boss B Lion's Mane dosage matches clinical trials - the extract has been tested, studied and chosen for its bioavailability. 

Lion's mane is not just another wellness hype. It's about real results rooted in science and it's delivered in one single gummy.

Thinking about upgrading your brain health, do it the smart way.

ADHD

Cortisol study

What Is Lion’s Mane and How Can It Support Stress and Brain Health?

Lion’s Mane is a functional mushroom that’s gaining attention for its potential benefits in supporting brain health, mood, and mental clarity.

Key Benefits

Lion’s Mane contains natural compounds that may:

● Support the growth and repair of brain cells

● Help improve memory and focus

● Reduce inflammation and oxidative stress

● Act as a natural adaptogen, helping the body respond to stress more effectively

How It Works

Lion’s Mane supports the nervous system by stimulating a protein called nerve growth factor (NGF), which plays a key role in the growth and repair of brain cells. It may also help balance important brain chemicals like serotonin and dopamine, which are linked to mood, concentration, and emotional resilience.

What the Research Shows

Several early human studies suggest potential benefits for brain function and mood:

Young Adults:

A 4-week study found that participants who took Lion’s Mane daily experienced improved focus and reported feeling less stressed, though more research is needed to confirm its effect on stress hormones like cortisol.

Older Adults:

In a 16-week study involving adults aged 50–80, Lion’s Mane improved memory and mental clarity. However, the benefits faded after they stopped taking the supplement.

Menopausal Women:

A small study found that Lion’s Mane helped reduce irritability, anxiety, and mood swings when taken daily in a low-dose cookie form over four weeks.

Single Dose Effects:

One short-term study showed improved hand-eye coordination shortly after taking Lion’s Mane, but no major changes in mood or stress were observed after just one dose.

Why It May Help with Stress

● Stimulates brain-repair proteins (NGF and BDNF)

● Reduces inflammation linked to chronic stress

● Helps rebalance brain chemicals that affect mood and resilience