Cortisol

What Is Lion’s Mane and How Can It Support Stress and Brain Health?

Lion’s Mane is a functional mushroom that’s gaining attention for its potential benefits in supporting brain health, mood, and mental clarity.

Key Benefits

Lion’s Mane contains natural compounds that may:

  • Support the growth and repair of brain cells
  • Help improve memory and focus
  • Reduce inflammation and oxidative stress
  • Act as a natural adaptogen, helping the body respond to stress more effectively


How It Works

Lion’s Mane supports the nervous system by stimulating a protein called nerve growth factor (NGF), which plays a key role in the growth and repair of brain cells. It may also help balance important brain chemicals like serotonin and dopamine, which are linked to mood, concentration, and emotional resilience.

What the Research Shows

Several early human studies suggest potential benefits for brain function and mood:

Young Adults:

A 4-week study found that participants who took Lion’s Mane daily experienced improved focus and reported feeling less stressed, though more research is needed to confirm its effect on stress hormones like cortisol.

Older Adults:

In a 16-week study involving adults aged 50–80, Lion’s Mane improved memory and mental clarity. However, the benefits faded after they stopped taking the supplement.

Menopausal Women:

A small study found that Lion’s Mane helped reduce irritability, anxiety, and mood swings when taken daily in a low-dose cookie form over four weeks.


Single Dose Effects:

One short-term study showed improved hand-eye coordination shortly after taking Lion’s Mane, but no major changes in mood or stress were observed after just one dose.

Why It May Help with Stress

  • Stimulates brain-repair proteins (NGF and BDNF)
  • Reduces inflammation linked to chronic stress
  • Helps rebalance brain chemicals that affect mood and resilience


Summary of Key Studies Study Type

Participants

Dose & Duration

Outcomes

Young adults

41 participants

1.8 g/day for 28 days

Improved focus, reduced self-reported stress

Older adults

Ages 50–80

3 g/day for 16 weeks

Improved memory during supplementation

Menopausal women

30 participants

2 g/day for 4 weeks

Reduced anxiety, irritability, mood swings

Single dose trial

Healthy adults

1.8 g once

Slight task improvement, no mood change

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